Apostle Isi Igenegba began her ministry journey as a Resident Pastor at Topfaith Ministries International in Ghana from October 2005 to June 2008.

In this role, she demonstrated her commitment to guiding and nurturing congregants while gaining valuable experience in church leadership.

From March 2013 to June 2015, she served as the Resident Pastor and Chief Administrator at This Present House, a flagship church of the House of Freedom. This Present House is known for its influential role in societal transformation and leadership development.

Apostle Isi led a congregation of over 2,000 professionals, providing vision and direction, designing training programs, and overseeing resource allocation.

She played a key role in fundraising and policy development, significantly impacting the church’s infrastructure and operational efficiency.

Since 2017, Apostle Isi Igenegba has led the People of Influence Network, making significant strides in advancing the Kingdom of God. Her dynamic leadership and visionary approach have transformed this network into a powerful platform for empowerment and societal impact, raising leaders and advocating for positive change globally.

The People of Influence Network is a multifaceted ministry with several key expressions:

This is Jacob: An initiative focused on men, empowering them to step into their God-given roles as leaders in their families, communities, and the world.

Children of Influence: A ministry dedicated to equipping the next generation with strong spiritual foundations and practical leadership skills.

Prison Ministry: A mission to bring hope, restoration, and the transformative power of the gospel to incarcerated individuals, providing them with spiritual, emotional, and practical support.

Influence Academy: The training hub of the ministry, designed to equip leaders with the necessary tools, strategies, and biblical principles to drive transformation in various sectors.

Apostle Isi also hosts Prayer Rain, a monthly global fasting and prayer program for apostolic discipleship and strategic intercession. Through this initiative, believers engage in focused prayers that bring transformation to their lives, communities, and nations.

Through her dynamic teaching ministry, she has ministered on several platforms across the world, including Ecclesia Hills, RIG Global, The Covenant Nation, House on the Rock Abuja, Action Chapel Ghana, and many others, where she continues to equip individuals and organizations for impactful change.

In 2022, Apostle Isi Igenegba launched the Mantle of Deborah movement, which has made significant progress, impacting over 5,000 women across Africa and recently expanding to Europe and America.

This initiative is known for its transformative conferences that address real-world challenges through collaboration and thought leadership. The Mantle of Deborah conferences bring diverse thought leaders and professionals, ensuring a blend of spiritual teachings with practical solutions.

The movement has made significant strides in various countries, including Nigeria, Kenya, South Africa, Ghana, Botswana, the United Kingdom, France, Uganda, and the United States.

Apostle Isi's partnerships with industry bodies and other ministry leaders have enhanced the relevance and impact of the training content.

The Mantle of Deborah's training initiatives are closely aligned with industry needs, leveraging partnerships with industry bodies, chambers of commerce, and corporate organizations.

Guest trainers from various sectors share their expertise, ensuring that training content is relevant and impactful. Government figures also participate in conferences and programs, contributing to actionable strategies and policy recommendations that drive societal transformation.

The movement has given rise to initiatives like the Deborah School of Influence and The Builders' Conference in Uganda.

These programs exemplify the movement’s dedication to nurturing leadership and driving real-world change through a blend of spiritual guidance and practical application.

Currently, Apostle Isi serves as the Africa Lead for Lou Engle's 'One Million Women Prayer Rally 2024.'

She rallies women across all African nations to intercede for their nations on the Day of Atonement, October 12, 2024.

This role underscores her ongoing commitment to global intercession and spiritual leadership, uniting women across the continent in prayer and advocacy for national and global transformation.